When caring for a client receiving TPN via central venous catheter (CVC) and antibiotics, what initial action should the nurse take before antibiotic administration?

In the scenario of a client receiving Total Parenteral Nutrition (TPN) through a central venous catheter (CVC) while also requiring antibiotics, the priority action is to ensure a separate intravenous access for the administration of IV antibiotics. Using a separate IV access for antibiotics is important for several reasons.

Firstly, TPN solutions contain a high concentration of dextrose and other nutrients, which can lead to incompatibility issues when mixed with certain medications, including antibiotics. Administering antibiotics through the same line could result in precipitate formation or adverse reactions that could compromise the client's safety and therapy effectiveness.

Secondly, having a separate line helps maintain the integrity of TPN therapy, allowing for consistent nutrient delivery without interference from other medications. This ensures the client continues to receive the necessary calories and nutrients without interruption or risk of contamination from antibiotic administration.

While checking compatibility with TPN, flushing the IV access, or stopping TPN could be considerations, they are not preferred initial actions when a separate IV access can effectively manage both therapies without complications.